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PHYSICS COLLOQUIUM
California State University Long Beach
Monday, October 20, 2014
11:15 am, PH2-110
(Refreshments served at 10:45am in HSCI-224)
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Theoretical Approaches towards HIV Vaccine Designs and Prevention Efforts
Ha Youn Lee
Department of Molecular Microbiology and Immunology
Keck School of Medicine, University of Southern California
Controlling and eradicating an unprecedented HIV/AIDS pandemic will require a better surveillance tool and improved vaccine design. Here we demonstrate how mathematical and computational tools originating from statistical physics can be used to advance HIV research. An effective HIV vaccine must contain antigens that recognize as many HIV peptides as possible, and the surface morphology of peptide-MHC (pMHC) complexes is one of the key factors controlling immune response breadth. Our design for predicting pMHC surface morphology assembles homology-based models and all-atom molecular dynamics simulations. Once a functional HIV vaccine is implemented, monitoring HIV incidence, the number of newly infected people, is necessary to evaluate its efficacy.
Our lab has focused on developing HIV genomic incidence assays utilizing signatures embedded in an individual?s HIV sequence population and quantifying the amount of evolution as a fingerprint of infection duration. Furthermore, mathematical modeling has allowed us to extend our accuracy in determining infection duration for recently infected individuals. Taken together, analytical approaches are becoming indispensable components to medical research
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Colloquium:
Monday, 11:15am, PH2-110
(unless specified otherwise)
Coordinator:
Dr. Andreas Bill, Email: abill@csulb.edu, Tel: +1-562-985-8616
Web site: www.csulb.edu/depts/physics
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