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Some people consider this approach (#3) to be "the" big idea
that you get from DoE. I'm not sure I agree; I attack with both
edges of a two-edged sword:
-- there are other good ideas in DoE, and
-- the "factorial analysis" (partial or otherwise) idea isn't
nearly as useful as some partisans seem to suggest.
To the extent that DoE suggests you can attack hard problems without
any understanding, it is a Bad Idea.
Someday you might be lucky enough to be presented
with a problem that is "just barely intractable" so that
a trick like partial factorial analysis makes a real difference,
but I wouldn't plan on it if I were you
My view of the principles goes like this:
++ The future lies in between: what we need are principles
and systematic methods for capturing _partial_ understanding,
and then doing a search guided by this partial understanding.
This is a topic that is ripe for good research -- research
into the principles, as opposed to just adding to the
bestiary of ad-hoc heuristics.