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Hi Jim-cut
Your question seems to be, broadly speaking, what is the nature of knowledge?
Thales, Anaximenes, and Anaximander (all at Miletus) tried to postulate a minimum of universal substances from which all matter was composed. The first two respectively named water and air as the primordial substance, Anaximander said that the primordial substance was unnameable (all this as reported by Aristotle). Fire was added by Heracleitus. Empedocles added earth, but he was already asking a